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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732555
Species: Homo sapiens
RGD Object: Gene
Symbol: GJB1
Name: gap junction protein beta 1
Acc ID: CHEBI:16130
Term: DDT
Definition: A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide.
Chemical ID: MESH:D003634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GJB1decreases expressionISOGjb1 (Rattus norvegicus)6480464CTDDDT results in decreased expression of GJB1 proteinPMID:8242434
GJB1multiple interactionsISOGjb1 (Rattus norvegicus)6480464CTD[DDT co-treated with Diethylnitrosamine] results in decreased expression of GJB1 mRNA; [DDT co-treated with Diethylnitrosamine] results in increased expression of GJB1 mRNAPMID:15885732
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