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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69169
Species: Mus musculus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:16130
Term: DDT
Definition: A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide.
Chemical ID: MESH:D003634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargmultiple interactionsEXP 6480464CTDDDT binds to and results in increased activity of PPARG protein; DDT results in increased activity of and results in increased localization of PPARG proteinPMID:11911853 PMID:33049310
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTDDDT results in increased expression of PPARG mRNAPMID:25014179
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTDDDT binds to and results in increased activity of PPARG proteinPMID:33049310
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