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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10790
Species: Mus musculus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:16130
Term: DDT
Definition: A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide.
Chemical ID: MESH:D003634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bdecreases expressionEXP 6480464CTDDDT metabolite results in decreased expression of IL1B mRNA; DDT results in decreased expression of IL1B mRNAPMID:12007859
Il1bmultiple interactionsEXP 6480464CTD[DDT co-treated with o,p'-DDT] results in decreased expression of IL1B mRNAPMID:12007859
Il1bincreases secretionISOIL1B (Homo sapiens)6480464CTDDDT results in increased secretion of IL1B proteinPMID:27592000
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