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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:16130
Term: DDT
Definition: A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide.
Chemical ID: MESH:D003634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2increases activityISOEsr2 (Rattus norvegicus)6480464CTDDDT results in increased activity of ESR2 proteinPMID:9860891
Esr2increases activityISOESR2 (Homo sapiens)6480464CTDDDT results in increased activity of ESR2 proteinPMID:15064155 PMID:26139245 PMID:26812056
Esr2multiple interactionsISOEsr2 (Rattus norvegicus)6480464CTD[o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Methoxychlor co-treated with Endosulfan co-treated with DDT] results in increased activity of ESR2 proteinPMID:9860891
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTDDDT binds to and results in increased activity of ESR2 proteinPMID:16626760 PMID:33049310
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