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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:16119
Term: shikimic acid
Definition: A cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid substituted by hydroxy groups at positions 3, 4 and 5 (the 3R,4S,5R stereoisomer). It is an intermediate metabolite in plants and microorganisms.
Chemical ID: MESH:D012765
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:685566480464CTDShikimic Acid results in increased expression of CCND1 mRNA, Shikimic Acid results in increased expression of CCND1 protein

PMID:31048002
multiple interactionsISORGD:685566480464CTDMIR300 mRNA affects the reaction [Shikimic Acid results in increased expression of CCND1 protein], pyrrolidine dithiocarbamic acid inhibits the reaction [Shikimic Acid results in increased expression of CCND1 mRNA]

PMID:31048002
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.