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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70837
Species: Homo sapiens
RGD Object: Gene
Symbol: HGF
Name: hepatocyte growth factor
Acc ID: CHEBI:16118
Term: berberine
Definition: A botanical anti-fungal agent that has formula C20H18NO4.
Chemical ID: MESH:D001599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HGFincreases expressionEXP 6480464CTDBerberine results in increased expression of HGF mRNA; Berberine results in increased expression of HGF proteinPMID:29408570
HGFmultiple interactionsEXP 6480464CTD15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF mRNA]; 15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Berberine results in increased expression of HGF protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF mRNA]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF protein]; Dactinomycin inhibits the reaction [Berberine results in increased expression of HGF protein]; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein]PMID:29408570
HGFincreases expressionISOHgf (Mus musculus)6480464CTDBerberine results in increased expression of HGF mRNA; Berberine results in increased expression of HGF proteinPMID:29408570
HGFmultiple interactionsISOHgf (Mus musculus)6480464CTDBerberine inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]PMID:29408570
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