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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619570
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK3
Name: mitogen-activated protein kinase 3
Acc ID: CHEBI:16118
Term: berberine
Definition: A botanical anti-fungal agent that has formula C20H18NO4.
Chemical ID: MESH:D001599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK3decreases phosphorylationISOMapk3 (Rattus norvegicus)6480464CTDBerberine results in decreased phosphorylation of MAPK3 proteinPMID:18294404
MAPK3multiple interactionsISOMapk3 (Mus musculus)6480464CTDBerberine inhibits the reaction [Dexamethasone results in decreased expression of MAPK3 mRNA]PMID:20462044
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