Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620298
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcg5
Name: ATP binding cassette subfamily G member 5
Acc ID: CHEBI:16113
Term: cholesterol
Definition: A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.
Chemical ID: MESH:D002784
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcg5decreases expressionEXP 6480464CTDCholesterol results in decreased expression of ABCG5 mRNAPMID:15683829
Abcg5increases expressionEXP 6480464CTDCholesterol results in increased expression of ABCG5 mRNAPMID:15683829
Abcg5multiple interactionsEXP 6480464CTD[Diosgenin results in increased expression of ABCG5 mRNA] which results in increased secretion of Cholesterol; [Ethinyl Estradiol results in decreased expression of ABCG5 mRNA] which results in decreased secretion of CholesterolPMID:12963437
Abcg5affects exportISOABCG5 (Homo sapiens)6480464CTDABCG5 protein affects the export of CholesterolPMID:15696852
Abcg5increases expressionISOAbcg5 (Mus musculus)6480464CTDCholesterol results in increased expression of ABCG5 mRNAPMID:15683829
Abcg5increases secretionISOAbcg5 (Mus musculus)6480464CTDABCG5 protein results in increased secretion of CholesterolPMID:15611112
Abcg5multiple interactionsISOAbcg5 (Mus musculus)6480464CTD[Cholesterol deficiency co-treated with Dietary Fats] results in decreased expression of ABCG5 mRNA; Cholates promotes the reaction [ABCG5 protein results in increased secretion of Cholesterol]; Diosgenin promotes the reaction [ABCG5 protein results in increased secretion of Cholesterol]PMID:15611112 PMID:18356535
Go Back to source page   Continue to Ontology report