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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:16113
Term: cholesterol
Definition: A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.
Chemical ID: MESH:D002784
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDCholesterol results in increased expression of CYP7A1 mRNA

PMID:21535835
increases metabolic processingEXP 6480464CTDCYP7A1 protein results in increased metabolism of Cholesterol

PMID:1175606
multiple interactionsEXP 6480464CTDturmeric extract promotes the reaction [Cholesterol results in increased expression of CYP7A1 mRNA]

PMID:21535835
affects metabolic processingISORGD:692106480464CTDCYP7A1 protein affects the metabolism of Cholesterol

PMID:15696852
increases metabolic processingISORGD:692106480464CTDCYP7A1 protein results in increased metabolism of Cholesterol

PMID:11013305, PMID:7925343
multiple interactionsISORGD:692106480464CTDCYP7A1 mRNA inhibits the reaction [Cholesterol results in increased phosphorylation of EIF4EBP1 protein], CYP7A1 mRNA inhibits the reaction [Cholesterol results in increased phosphorylation of GSK3B protein], CYP7A1 mRNA inhibits the reaction [Cholesterol results in increased phosphorylation of RPS6 protein], CYP7A1 mRNA inhibits the reaction [Tretinoin results in increased abundance of Cholesterol]

PMID:28275691, PMID:30709899
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.