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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:16113
Term: cholesterol
Definition: A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.
Chemical ID: MESH:D002784
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp7a1increases expressionEXP 6480464CTDCholesterol results in increased expression of CYP7A1 mRNAPMID:21535835
Cyp7a1increases metabolic processingEXP 6480464CTDCYP7A1 protein results in increased metabolism of CholesterolPMID:1175606
Cyp7a1multiple interactionsEXP 6480464CTDturmeric extract promotes the reaction [Cholesterol results in increased expression of CYP7A1 mRNA]PMID:21535835
Cyp7a1affects metabolic processingISOCYP7A1 (Homo sapiens)6480464CTDCYP7A1 protein affects the metabolism of CholesterolPMID:15696852
Cyp7a1increases metabolic processingISOCYP7A1 (Homo sapiens)6480464CTDCYP7A1 protein results in increased metabolism of CholesterolPMID:11013305 PMID:7925343
Cyp7a1multiple interactionsISOCYP7A1 (Homo sapiens)6480464CTDCYP7A1 mRNA inhibits the reaction [Cholesterol results in increased phosphorylation of EIF4EBP1 protein]; CYP7A1 mRNA inhibits the reaction [Cholesterol results in increased phosphorylation of GSK3B protein]; CYP7A1 mRNA inhibits the reaction [Cholesterol results in increased phosphorylation of RPS6 protein]; CYP7A1 mRNA inhibits the reaction [Tretinoin results in increased abundance of Cholesterol]PMID:28275691 PMID:30709899
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