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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1614945
Species: Mus musculus
RGD Object: Gene
Symbol: Marchf6
Name: membrane associated ring-CH-type finger 6
Acc ID: CHEBI:16113
Term: cholesterol
Definition: A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.
Chemical ID: MESH:D002784
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Marchf6increases stabilityISOMARCHF6 (Homo sapiens)6480464CTDCholesterol results in increased stability of MARCHF6 proteinPMID:30545937
Marchf6multiple interactionsISOMARCHF6 (Homo sapiens)6480464CTDCholesterol inhibits the reaction [Betaine results in decreased stability of MARCHF6 protein]; Cholesterol inhibits the reaction [Glycerol results in decreased stability of MARCHF6 protein]; Cholesterol inhibits the reaction [MARCHF6 protein results in increased ubiquitination of and results in increased degradation of MARCHF6 protein]; MARCHF6 promotes the reaction [Cholesterol results in increased degradation of SQLE protein]PMID:30545937
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