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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306605
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp46a1
Name: cytochrome P450, family 46, subfamily a, polypeptide 1
Acc ID: CHEBI:16113
Term: cholesterol
Definition: A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.
Chemical ID: MESH:D002784
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp46a1increases hydroxylationISOCYP46A1 (Homo sapiens)6480464CTDCYP46A1 protein results in increased hydroxylation of CholesterolPMID:14640697
Cyp46a1multiple interactionsISOCYP46A1 (Homo sapiens)6480464CTDCYP46A1 gene SNP affects the metabolism of and affects the abundance of CholesterolPMID:19286353
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