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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:16112
Term: chlorogenic acid
Definition: A cinnamate ester obtained by formal condensation of the carboxy group of trans-caffeic acid with the 3-hydroxy group of quinic acid. It is an intermediate metabolite in the biosynthesis of lignin.
Chemical ID: MESH:D002726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDChlorogenic Acid results in increased expression of NQO1 mRNA

PMID:29136249
multiple interactionsEXP 6480464CTDChlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of NQO1 mRNA], Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of NQO1 protein]

PMID:29136249
increases activityISORGD:104736480464CTDChlorogenic Acid results in increased activity of NQO1 protein

PMID:15944151
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.