Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	733199
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Top1
Name:	topoisomerase (DNA) I

Acc ID:	CHEBI:16096
Term:	palmatine
Definition:	A berberine alkaloid that has formula C21H22NO4.
Chemical ID:	MESH:C005413

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Top1	decreases activity	ISO	TOP1 (Homo sapiens)	6480464	CTD	palmatine results in decreased activity of TOP1 protein	PMID:23747414

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.