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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733100
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2
Name: BCL2 apoptosis regulator
Acc ID: CHEBI:16015
Term: L-glutamic acid
Definition: An optically active form of glutamic acid having L-configuration.
Chemical ID: MESH:D018698
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2decreases expressionEXP 6480464CTDGlutamic Acid results in decreased expression of BCL2 proteinPMID:33617922
BCL2multiple interactionsEXP 6480464CTDdihydroactinidiolide inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]PMID:33617922
BCL2decreases expressionISOBcl2 (Rattus norvegicus)6480464CTDGlutamic Acid results in decreased expression of BCL2 proteinPMID:32092300 PMID:35028790
BCL2multiple interactionsISOBcl2 (Rattus norvegicus)6480464CTD1,3-benzothiazol-2-yl(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]]; Memantine analog inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]; Memantine inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]; MKC8866 promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]]; shikonin inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]; ursodoxicoltaurine inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]; ursodoxicoltaurine inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]]PMID:32092300 PMID:35028790
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