GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | HCAR2 | affects binding | EXP | | 6480464 | CTD | Niacin binds to HCAR2 protein | PMID:16099840 | HCAR2 | increases activity | EXP | | 6480464 | CTD | Niacin results in increased activity of HCAR2 protein | PMID:15929991 PMID:19223991 | HCAR2 | multiple interactions | EXP | | 6480464 | CTD | [Niacin binds to and results in increased activity of HCAR2 protein] which results in increased phosphorylation of MAPK1 protein; [Niacin binds to and results in increased activity of HCAR2 protein] which results in increased phosphorylation of MAPK3 protein; [Niacin results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; HCAR2 protein promotes the reaction [Niacin results in increased expression of and results in increased activity of PPARG protein]; Niacin binds to and affects the activity of HCAR2 protein; Niacin binds to and results in increased activity of HCAR2 protein | PMID:16018973 PMID:16386710 PMID:16389067 PMID:19223991 PMID:20380810 PMID:20452209 PMID:20460384 PMID:21167710 | HCAR2 | multiple interactions | ISO | Hcar2 (Rattus norvegicus) | 6480464 | CTD | [Niacin analog binds to and results in increased activity of HCAR2 protein] which results in decreased abundance of Fatty Acids, Nonesterified; [Niacin binds to and results in increased activity of HCAR2 protein] which results in decreased abundance of Fatty Acids, Nonesterified; Niacin binds to and results in increased activity of HCAR2 protein | PMID:17804224 PMID:19309152 | | ||||||||||||||||||||||
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