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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736797
Species: Homo sapiens
RGD Object: Gene
Symbol: INSL3
Name: insulin like 3
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
INSL3increases expressionEXP 6480464CTDAtrazine results in increased expression of INSL3 mRNAPMID:18585445
INSL3affects expressionISOInsl3 (Mus musculus)6480464CTDAtrazine affects the expression of INSL3 mRNAPMID:33463082
INSL3increases expressionISOInsl3 (Rattus norvegicus)6480464CTDAtrazine results in increased expression of INSL3 mRNAPMID:23200735 PMID:34600026
INSL3multiple interactionsISOInsl3 (Rattus norvegicus)6480464CTD[Atrazine co-treated with Bucladesine] results in increased expression of INSL3 mRNA; Atrazine inhibits the reaction [Bucladesine results in increased expression of INSL3 mRNA]; Quercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of INSL3 mRNA]; Quercetin inhibits the reaction [Atrazine results in increased expression of INSL3 mRNA]PMID:21693180 PMID:23200735
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