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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68493
Species: Homo sapiens
RGD Object: Gene
Symbol: NR5A1
Name: nuclear receptor subfamily 5 group A member 1
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR5A1affects bindingEXP 6480464CTDAtrazine binds to NR5A1 proteinPMID:17520059
NR5A1increases expressionEXP 6480464CTDAtrazine results in increased expression of NR5A1 mRNA; Atrazine results in increased expression of NR5A1 proteinPMID:17520059 PMID:22378314
NR5A1increases phosphorylationEXP 6480464CTDAtrazine results in increased phosphorylation of NR5A1 proteinPMID:18461179
NR5A1multiple interactionsEXP 6480464CTDAtrazine binds to and results in increased activity of NR5A1 protein; Atrazine promotes the reaction [[NR5A1 protein binds to CYP19A1 gene] which results in increased expression of CYP19A1 mRNA]; NR5A1 protein affects the reaction [Atrazine results in increased expression of CYP19A1 mRNA]; NR5A1 protein affects the reaction [Atrazine results in increased expression of LHB mRNA]; NR5A1 protein promotes the reaction [Atrazine results in increased expression of CYP11A1 mRNA]; NR5A1 protein promotes the reaction [Atrazine results in increased expression of CYP19A1 mRNA]; NR5A1 protein promotes the reaction [Atrazine results in increased expression of HSD11B2 mRNA]; NR5A1 protein promotes the reaction [Atrazine results in increased expression of INHA mRNA]; NR5A1 protein promotes the reaction [Atrazine results in increased expression of STAR mRNA]PMID:17331471 PMID:17520059 PMID:18461179
NR5A1decreases expressionISONr5a1 (Rattus norvegicus)6480464CTDAtrazine results in decreased expression of NR5A1 mRNAPMID:19541795
NR5A1increases activityISONr5a1 (Mus musculus)6480464CTDAtrazine results in increased activity of NR5A1 proteinPMID:18461179
NR5A1increases expressionISONr5a1 (Rattus norvegicus)6480464CTDAtrazine results in increased expression of NR5A1 mRNAPMID:20667998
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