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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620436
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cga
Name: glycoprotein hormones, alpha polypeptide
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects methylationEXP 6480464CTDAtrazine affects the methylation of CGA gene

PMID:28931070
multiple interactionsEXP 6480464CTD[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of AREG mRNA], [Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of EREG mRNA], [Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of PGR mRNA], [CGA protein affects the susceptibility to Atrazine] which results in increased expression of SCARB1 mRNA, [CGA protein affects the susceptibility to Atrazine] which results in increased expression of STAR mRNA, [CGA protein co-treated with Atrazine] results in increased expression of STAR mRNA, [Egtazic Acid co-treated with 1, 2-bis(2-aminophenoxy)ethane N, N, N', N'-tetraacetic acid acetoxymethyl ester] inhibits the reaction [[CGA protein co-treated with Atrazine] results in increased expression of STAR mRNA], bisindolylmaleimide I inhibits the reaction [[CGA protein co-treated with Atrazine] results in increased expression of STAR mRNA], U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of AREG mRNA]], U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of EREG mRNA]], U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]]

PMID:23583632, PMID:27554787
increases expressionISORGD:13485906480464CTDAtrazine results in increased expression of CGA mRNA

PMID:18461179
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.