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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
Acc ID: CHEBI:15891
Term: taurine
Definition: An amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid. It is a naturally occurring amino acid derived from methionine and cysteine metabolism. An abundant component of fish- and meat-based foods, it has been used as an oral supplement in the treatment of disorders such as cystic fibrosis and hypertension.
Chemical ID: MESH:D013654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2E1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTDTaurine inhibits the reaction [Acetaminophen results in increased activity of CYP2E1 protein]; Taurine inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]PMID:20067817 PMID:20166895
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