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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318015
Species: Mus musculus
RGD Object: Gene
Symbol: Nlrp3
Name: NLR family, pyrin domain containing 3
Acc ID: CHEBI:15891
Term: taurine
Definition: An amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid. It is a naturally occurring amino acid derived from methionine and cysteine metabolism. An abundant component of fish- and meat-based foods, it has been used as an oral supplement in the treatment of disorders such as cystic fibrosis and hypertension.
Chemical ID: MESH:D013654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nlrp3multiple interactionsEXP 6480464CTDTaurine inhibits the reaction [Arsenic Trioxide results in increased expression of NLRP3 protein]PMID:30237538
Nlrp3multiple interactionsISONlrp3 (Rattus norvegicus)6480464CTDTaurine inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein]; Taurine inhibits the reaction [Arsenic Trioxide results in increased expression of NLRP3 protein]PMID:30660605
Nlrp3multiple interactionsISONLRP3 (Homo sapiens)6480464CTDTaurine inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 protein]PMID:30237538
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