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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736306
Species: Homo sapiens
RGD Object: Gene
Symbol: IL4
Name: interleukin 4
Acc ID: CHEBI:15864
Term: luteolin
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4', 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers.
Chemical ID: MESH:D047311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL4decreases expressionEXP 6480464CTDLuteolin results in decreased expression of IL4 proteinPMID:16343431
IL4multiple interactionsEXP 6480464CTDLuteolin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4]PMID:16601352
IL4decreases expressionISOIl4 (Mus musculus)6480464CTDLuteolin results in decreased expression of IL4 proteinPMID:12755373
IL4multiple interactionsISOIl4 (Rattus norvegicus)6480464CTDLuteolin inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA]PMID:17950587
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