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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:15864
Term: luteolin
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4' 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an inflammatory agent and an immune system modulator as well as being active against several cancers.
Chemical ID: MESH:D047311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDLuteolin inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA]

PMID:17950587
decreases expressionISORGD:107966480464CTDLuteolin results in decreased expression of IL4 protein

PMID:12755373
decreases expressionISORGD:7363066480464CTDLuteolin results in decreased expression of IL4 protein

PMID:16343431
multiple interactionsISORGD:7363066480464CTDLuteolin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4]

PMID:16601352
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.