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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:15864
Term: luteolin
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4', 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers.
Chemical ID: MESH:D047311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1decreases activityISOCYP1A1 (Homo sapiens)6480464CTDLuteolin results in decreased activity of CYP1A1 proteinPMID:21482471
Cyp1a1decreases expressionISOCYP1A1 (Homo sapiens)6480464CTDLuteolin results in decreased expression of CYP1A1 proteinPMID:33727136
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDLuteolin results in increased expression of CYP1A1 mRNAPMID:20930378
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDLuteolin results in increased expression of CYP1A1 mRNAPMID:20403331 PMID:23994263 PMID:29584932
Cyp1a1increases response to substanceISOCYP1A1 (Homo sapiens)6480464CTDCYP1A1 protein results in increased susceptibility to LuteolinPMID:33727136
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTDLuteolin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]PMID:20930378
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD[CYP1A1 protein results in increased susceptibility to Luteolin] which results in decreased abundance of diosmetin; CYP1A1 protein promotes the reaction [Luteolin results in increased cleavage of CASP3 protein]; CYP1A1 protein promotes the reaction [Luteolin results in increased cleavage of PARP1 protein]; CYP1A1 protein promotes the reaction [Luteolin results in increased expression of H2AX protein]; Luteolin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Dust analog results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Particulate Matter analog results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Vehicle Emissions analog results in increased expression of CYP1A1 mRNA]PMID:16263508 PMID:17090139 PMID:20403331 PMID:33727136
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