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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735872
Species: Homo sapiens
RGD Object: Gene
Symbol: PLA2G4A
Name: phospholipase A2 group IVA
Acc ID: CHEBI:15843
Term: arachidonic acid
Definition: A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.
Chemical ID: MESH:D016718
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PLA2G4Aincreases expressionEXP 6480464CTDArachidonic Acid results in increased expression of PLA2G4A mRNA; Arachidonic Acid results in increased expression of PLA2G4A proteinPMID:15878913
PLA2G4Amultiple interactionsEXP 6480464CTDAHR affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [PLA2G4A protein results in increased secretion of Arachidonic Acid]]; Dinoprostone promotes the reaction [Arachidonic Acid results in increased expression of PLA2G4A mRNA]; Flurbiprofen inhibits the reaction [Arachidonic Acid results in increased expression of PLA2G4A mRNA]PMID:15878913 PMID:19162293
PLA2G4Amultiple interactionsISOPla2g4a (Rattus norvegicus)6480464CTDPLA2G4A protein promotes the reaction [2,2',4,6-tetrachlorobiphenyl results in increased secretion of Arachidonic Acid]PMID:16120751
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