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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732503
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:15843
Term: arachidonic acid
Definition: A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.
Chemical ID: MESH:D016718
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTDArachidonic Acid results in increased phosphorylation of MAPK1 proteinPMID:19464254
Mapk1multiple interactionsEXP 6480464CTD[Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK1 protein; CYP2C23 mRNA promotes the reaction [[Arachidonic Acid co-treated with VEGFA protein] results in increased phosphorylation of MAPK1 protein]; CYP2C23 mRNA promotes the reaction [Arachidonic Acid results in increased phosphorylation of MAPK1 protein]PMID:19464254
Mapk1affects abundanceISOMapk1 (Rattus norvegicus)6480464CTDMAPK1 protein affects the abundance of Arachidonic AcidPMID:16216387
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