GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | FOXO1 | decreases expression | ISO | Foxo1 (Mus musculus) | 6480464 | CTD | Palmitic Acid results in decreased expression of FOXO1 mRNA; Palmitic Acid results in decreased expression of FOXO1 protein | PMID:36030031 | FOXO1 | decreases phosphorylation | ISO | Foxo1 (Rattus norvegicus) | 6480464 | CTD | Palmitic Acid results in decreased phosphorylation of FOXO1 protein | PMID:22819839 | FOXO1 | decreases phosphorylation | ISO | Foxo1 (Mus musculus) | 6480464 | CTD | Palmitic Acid results in decreased phosphorylation of FOXO1 protein | PMID:21255808 | FOXO1 | increases localization | ISO | Foxo1 (Rattus norvegicus) | 6480464 | CTD | Palmitic Acid results in increased localization of FOXO1 protein | PMID:22968147 | FOXO1 | multiple interactions | ISO | Foxo1 (Rattus norvegicus) | 6480464 | CTD | geniposide inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]; resveratrol inhibits the reaction [Palmitic Acid results in increased localization of FOXO1 protein] | PMID:22819839 PMID:22968147 | FOXO1 | multiple interactions | ISO | Foxo1 (Mus musculus) | 6480464 | CTD | 4-methylumbelliferone 8-carbaldehyde inhibits the reaction [Palmitic Acid results in decreased expression of FOXO1 mRNA]; 4-methylumbelliferone 8-carbaldehyde inhibits the reaction [Palmitic Acid results in decreased expression of FOXO1 protein]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid results in decreased expression of FOXO1 mRNA]; 4-phenylbutyric acid inhibits the reaction [Palmitic Acid results in decreased expression of FOXO1 protein]; [GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]; [Oleic Acid co-treated with Palmitic Acid] results in decreased phosphorylation of FOXO1 protein; [Palmitic Acid co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of FOXO1 mRNA; [sodium arsenite co-treated with Palmitic Acid co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of FOXO1 mRNA; candesartan inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]; FOXO1 protein affects the reaction [[Oleic Acid co-treated with Palmitic Acid] inhibits the reaction [INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of G6PC1 protein]]]; FOXO1 protein affects the reaction [[Oleic Acid co-treated with Palmitic Acid] inhibits the reaction [INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of PEPCK protein]]]; FOXO1 protein affects the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of NFE2L2 mRNA]; FOXO1 protein affects the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of NRF1 mRNA]; FOXO1 protein affects the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARGC1A mRNA]; FOXO1 protein affects the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of TFAM mRNA]; GCG protein inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]; GSK2656157 inhibits the reaction [Palmitic Acid results in decreased expression of FOXO1 mRNA]; Palmitic Acid inhibits the reaction [sodium arsenite results in increased expression of FOXO1 mRNA] | PMID:21255808 PMID:26847930 PMID:34968464 PMID:36030031 | | ||||||||||||||||||||||
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