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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:15756
Term: hexadecanoic acid
Definition: A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Chemical ID: MESH:D019308
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Oleic Acid co-treated with Palmitic Acid co-treated with Ethanol] results in increased expression of SREBF1 protein, [Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA, quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA]

PMID:26190035, PMID:26854922
increases expressionISORGD:694736480464CTDPalmitic Acid results in increased expression of SREBF1 protein

PMID:25943029, PMID:30208301
increases expressionISORGD:694746480464CTDPalmitic Acid results in increased expression of SREBF1 protein, Palmitic Acid results in increased expression of SREBF1 protein modified form

PMID:29414781, PMID:30208301
multiple interactionsISORGD:694736480464CTDATG5 protein promotes the reaction [Resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]], ATG7 protein affects the reaction [trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]], BECN1 protein promotes the reaction [Resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]], Resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein], trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]

PMID:25943029, PMID:30208301
multiple interactionsISORGD:694746480464CTDtrigonelline inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]

PMID:30208301
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.