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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:15756
Term: hexadecanoic acid
Definition: A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Chemical ID: MESH:D019308
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3multiple interactionsEXP 6480464CTDAICA ribonucleotide inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]; Metformin inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]; Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]; Resveratrol inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]; Salicylic Acid inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]PMID:25108154
Nos3multiple interactionsISONOS3 (Homo sapiens)6480464CTD3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]]; Agmatine inhibits the reaction [Palmitic Acid results in increased activity of and results in decreased phosphorylation of NOS3 protein]; dorsomorphin inhibits the reaction [Agmatine inhibits the reaction [Palmitic Acid results in increased activity of and results in decreased phosphorylation of NOS3 protein]]; Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]; Palmitic Acid results in increased activity of and results in decreased phosphorylation of NOS3 protein; tin protoporphyrin IX inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]]]PMID:25815690 PMID:35747990
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