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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:15756
Term: hexadecanoic acid
Definition: A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Chemical ID: MESH:D019308
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDPalmitic Acid results in increased expression of BAX; Palmitic Acid results in increased expression of BAX proteinPMID:15945276 PMID:34897970
Baxmultiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of BAX protein]]; [Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of BAX protein]; MIR141 mRNA promotes the reaction [Palmitic Acid results in increased expression of BAX protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of BAX protein]]PMID:34897970
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDPalmitic Acid affects the expression of BAX mRNAPMID:33736254
Baxincreases expressionISOBax (Mus musculus)6480464CTDPalmitic Acid results in increased expression of BAX proteinPMID:32905826 PMID:34678374
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDPalmitic Acid results in increased expression of BAXPMID:15945276
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDamlexanox inhibits the reaction [Palmitic Acid results in increased expression of BAX protein]; carnosol inhibits the reaction [Palmitic Acid results in increased expression of BAX protein]; PRDX3 protein inhibits the reaction [Palmitic Acid results in increased expression of BAX protein]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in increased expression of BAX protein]]PMID:32905826 PMID:34678374
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD3-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of BAX mRNA]; [Palmitic Acid co-treated with Arsenic] affects the expression of BAX mRNA; [Palmitic Acid co-treated with Oleic Acid] results in increased expression of BAX mRNAPMID:32369900 PMID:33736254
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