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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62159
Species: Mus musculus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:15738
Term: staurosporine
Definition: An indolocarbazole alkaloid that has formula C28H26N4O3.
Chemical ID: MESH:D019311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases activityISOCASP9 (Homo sapiens)6480464CTDStaurosporine results in increased activity of CASP9 proteinPMID:19352495 PMID:20338155 PMID:29458164 PMID:31730886 PMID:31926150 PMID:34302491
Casp9increases cleavageISOCASP9 (Homo sapiens)6480464CTDStaurosporine results in increased cleavage of CASP9 proteinPMID:26124276
Casp9multiple interactionsISOCasp9 (Rattus norvegicus)6480464CTD3-methyladenine promotes the reaction [Staurosporine results in increased cleavage of CASP9 protein]; Sirolimus inhibits the reaction [Staurosporine results in increased cleavage of CASP9 protein]PMID:16497721
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTDACHE protein affects the susceptibility to [Staurosporine results in increased activity of CASP9 protein]; Staurosporine results in increased cleavage of and results in increased activity of CASP9 proteinPMID:16007152 PMID:20338155
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