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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551988
Species: Mus musculus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase family, member 1
Acc ID: CHEBI:15738
Term: staurosporine
Definition: An indolocarbazole alkaloid that has formula C28H26N4O3.
Chemical ID: MESH:D019311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases cleavageEXP 6480464CTDStaurosporine results in increased cleavage of PARP1 proteinPMID:10704466 PMID:11035063 PMID:24740755
Parp1multiple interactionsEXP 6480464CTDSOD2 mutant form inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein]; Staurosporine affects the reaction [sodium arsenite results in increased cleavage of PARP1 protein]PMID:11035063 PMID:24740755
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDStaurosporine results in increased cleavage of PARP1 proteinPMID:18451153 PMID:21447800 PMID:24464939 PMID:27539959 PMID:30660566 PMID:37268255
Parp1increases expressionISOParp1 (Rattus norvegicus)6480464CTDStaurosporine results in increased expression of PARP1 protein modified formPMID:22639866
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTDEOMES protein inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein]; Silybin inhibits the reaction [Staurosporine promotes the reaction [Acetaldehyde results in increased cleavage of PARP1 protein]]; Staurosporine promotes the reaction [Acetaldehyde results in increased cleavage of PARP1 protein]PMID:27539959 PMID:35158046
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