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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619796
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cysltr1
Name: cysteinyl leukotriene receptor 1
Acc ID: CHEBI:15650
Term: leukotriene E4
Definition: A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and an L-cystein-S-yl group at position 6 (6R).
Chemical ID: MESH:D017999
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cysltr1affects bindingISOCYSLTR1 (Homo sapiens)6480464CTDLeukotriene E4 binds to CYSLTR1 proteinPMID:8384568
Cysltr1multiple interactionsISOCYSLTR1 (Homo sapiens)6480464CTD[Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium; Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein; montelukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]; zafirlukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]PMID:10462554 PMID:12853847 PMID:9620942
Cysltr1multiple interactionsISOCysltr1 (Mus musculus)6480464CTDLeukotriene E4 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]PMID:11705452
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