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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733100
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2
Name: BCL2 apoptosis regulator
Acc ID: CHEBI:15600
Term: (+)-catechin
Definition: The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.
Chemical ID: MESH:D002392
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2decreases expressionEXP 6480464CTDCatechin results in decreased expression of BCL2 mRNA; Catechin results in decreased expression of BCL2 proteinPMID:23706674
BCL2multiple interactionsEXP 6480464CTDCatechin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein]PMID:19557821
BCL2affects expressionISOBcl2 (Mus musculus)6480464CTDCatechin affects the expression of BCL2 mRNAPMID:26363153
BCL2multiple interactionsISOBcl2 (Mus musculus)6480464CTDQuercetin affects the reaction [Catechin affects the expression of BCL2 mRNA]PMID:26363153
BCL2multiple interactionsISOBcl2 (Rattus norvegicus)6480464CTDCatechin analog inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 mRNA]; Catechin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Catechin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]PMID:18611398 PMID:34027802
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