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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730981
Species: Homo sapiens
RGD Object: Gene
Symbol: IL1B
Name: interleukin 1 beta
Acc ID: CHEBI:15600
Term: (+)-catechin
Definition: The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.
Chemical ID: MESH:D002392
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL1Bmultiple interactionsEXP 6480464CTD[epigallocatechin gallate co-treated with gallocatechol co-treated with epicatechin gallate co-treated with Catechin analog] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Catechin analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Catechin inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Catechin inhibits the reaction [Glucose results in increased expression of IL1B protein]; Catechin inhibits the reaction [S100B protein results in increased expression of IL1B mRNA]PMID:17103373 PMID:19557821 PMID:26187476
IL1Bdecreases expressionISOIl1b (Mus musculus)6480464CTDCatechin results in decreased expression of IL1B proteinPMID:34581093
IL1Bmultiple interactionsISOIl1b (Rattus norvegicus)6480464CTDCatechin inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]PMID:35337893
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