Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

REFERENCE - CHEMICAL INTERACTIONS REPORT

RGD ID: 25824851
Species: All species
RGD Object: Reference
Acc ID: CHEBI:155824
Term: GSK2181236A
Definition: A biphenyl that is 1,1'-biphenyl substituted by a methyl group at position 3, a (2-{6-[4-carboxy-5-(trifluoromethyl)-1H-pyrazol-1-yl]pyridin-2-yl}phenoxy)methyl group at position 4 and by a trifluoromethoxy at position 4'. It is a potent guanylate cyclase activator.
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acta1decreases expression EXP 25824851RGDGSK2181236A decreases expression of Acta1 mRNA in rat myocardium 
Nppadecreases expression EXP 25824851RGDGSK2181236A decreases expression of Nppa mRNA in rat myocardium 
ACTA1decreases expression ISOActa1 (Rattus norvegicus)25824851RGDGSK2181236A decreases expression of Acta1 mRNA in rat myocardium 
Acta1decreases expression ISOActa1 (Rattus norvegicus)25824851RGDGSK2181236A decreases expression of Acta1 mRNA in rat myocardium 
NPPAdecreases expression ISONppa (Rattus norvegicus)25824851RGDGSK2181236A decreases expression of Nppa mRNA in rat myocardium 
Nppadecreases expression ISONppa (Rattus norvegicus)25824851RGDGSK2181236A decreases expression of Nppa mRNA in rat myocardium 
Go Back to source page   Continue to Ontology report