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RGD ID: 2025
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acta1
Name: actin, alpha 1, skeletal muscle
Acc ID: CHEBI:155824
Term: GSK2181236A
Definition: A biphenyl that is 1,1'-biphenyl substituted by a methyl group at position 3, a (2-{6-[4-carboxy-5-(trifluoromethyl)-1H-pyrazol-1-yl]pyridin-2-yl}phenoxy)methyl group at position 4 and by a trifluoromethoxy at position 4'. It is a potent guanylate cyclase activator.
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acta1decreases expression EXP 25824851RGDGSK2181236A decreases expression of Acta1 mRNA in rat myocardium

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.