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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735336
Species: Mus musculus
RGD Object: Gene
Symbol: Akt1
Name: thymoma viral proto-oncogene 1
Acc ID: CHEBI:15551
Term: prostaglandin E2
Definition: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.
Chemical ID: MESH:D015232
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1increases phosphorylationEXP 6480464CTDDinoprostone results in increased phosphorylation of AKT1 proteinPMID:30884126
Akt1multiple interactionsEXP 6480464CTDtaiwanin C inhibits the reaction [Dinoprostone results in increased phosphorylation of AKT1 protein]PMID:30884126
Akt1increases phosphorylationISOAKT1 (Homo sapiens)6480464CTDDinoprostone results in increased phosphorylation of AKT1 proteinPMID:17805209
Akt1multiple interactionsISOAkt1 (Rattus norvegicus)6480464CTDDinoprostone results in increased phosphorylation of and results in increased activity of AKT1 proteinPMID:16396944
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTDDinoprostone inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; gefitinib inhibits the reaction [Dinoprostone results in increased phosphorylation of AKT1 protein]PMID:17805209 PMID:23747687 PMID:25094029
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