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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730831
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP4A11
Name: cytochrome P450 family 4 subfamily A member 11
Acc ID: CHEBI:15551
Term: prostaglandin E2
Definition: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.
Chemical ID: MESH:D015232
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP4A11increases secretionEXP 6480464CTDCYP4A11 protein results in increased secretion of DinoprostonePMID:23747687
CYP4A11multiple interactionsEXP 6480464CTDisoliquiritigenin inhibits the reaction [CYP4A11 protein results in increased secretion of Dinoprostone]PMID:23747687
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