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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69659
Species: Homo sapiens
RGD Object: Gene
Symbol: ICAM1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:15551
Term: prostaglandin E2
Definition: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.
Chemical ID: MESH:D015232
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ICAM1increases expressionISOIcam1 (Mus musculus)6480464CTDDinoprostone results in increased expression of ICAM1 mRNA; Dinoprostone results in increased expression of ICAM1 proteinPMID:16777358
ICAM1multiple interactionsISOIcam1 (Mus musculus)6480464CTDDinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Cadmium Chloride results in increased expression of ICAM1 mRNA]]; Dinoprostone inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Cadmium Chloride results in increased expression of ICAM1 mRNA]]; Dinoprostone inhibits the reaction [Reactive Oxygen Species results in increased expression of ICAM1 mRNA]; Dinoprostone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]PMID:10495789 PMID:16777358
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