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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628641
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptger4
Name: prostaglandin E receptor 4
Acc ID: CHEBI:15551
Term: prostaglandin E2
Definition: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.
Chemical ID: MESH:D015232
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptger4increases expressionEXP 6480464CTDDinoprostone results in increased expression of PTGER4 mRNAPMID:10800959
Ptger4multiple interactionsEXP 6480464CTDPTGER4 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein]PMID:17408863
Ptger4increases activityISOPTGER4 (Homo sapiens)6480464CTDDinoprostone results in increased activity of PTGER4 proteinPMID:23526216
Ptger4increases expressionISOPTGER4 (Homo sapiens)6480464CTDDinoprostone results in increased expression of PTGER4 proteinPMID:30208247
Ptger4multiple interactionsISOPtger4 (Mus musculus)6480464CTDDinoprostone binds to and results in decreased activity of PTGER4 proteinPMID:12009843
Ptger4multiple interactionsISOPTGER4 (Homo sapiens)6480464CTD[[Dinoprostone results in increased activity of PTGER4 protein] which results in increased susceptibility to nickel sulfate] which results in increased secretion of CXCL8 protein; [Dinoprostone results in increased activity of PTGER4 protein] which results in increased chemical synthesis of Cyclic AMP; [Dinoprostone results in increased activity of PTGER4 protein] which results in increased susceptibility to nickel sulfate; cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of PTGER4 protein]; nickel sulfate promotes the reaction [[Dinoprostone results in increased activity of PTGER4 protein] which results in increased chemical synthesis of Cyclic AMP]PMID:23526216 PMID:30208247
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