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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3770
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Star
Name: steroidogenic acute regulatory protein
Acc ID: CHEBI:15551
Term: prostaglandin E2
Definition: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.
Chemical ID: MESH:D015232
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7354136480464CTDDinoprostone results in decreased expression of STAR mRNA

PMID:19253104
increases expressionISORGD:7354136480464CTDDinoprostone results in increased expression of STAR mRNA, Dinoprostone results in increased expression of STAR protein

PMID:19001523
multiple interactionsISORGD:7354136480464CTDDinoprostone inhibits the reaction [NR2F2 protein binds to STAR promoter], Dinoprostone inhibits the reaction [WT1 protein binds to STAR promoter], Dinoprostone promotes the reaction [NR5A1 protein binds to STAR promoter]

PMID:19001523
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.