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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1557448
Species: Mus musculus
RGD Object: Gene
Symbol: Top2b
Name: topoisomerase (DNA) II beta
Acc ID: CHEBI:15422
Term: ATP
Definition: An adenosine 5'-phosphate in which the 5'-phosphate is a triphosphate group. It is involved in the transportation of chemical energy during metabolic pathways.
Chemical ID: MESH:D000255
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top2bincreases hydrolysisISORGD:13506376480464CTDTOP2B protein results in increased hydrolysis of Adenosine Triphosphate

PMID:29272108
Top2bmultiple interactionsISORGD:13506376480464CTDcannabidiol hydroxyquinone inhibits the reaction [TOP2B protein results in increased hydrolysis of Adenosine Triphosphate], Cannabidiol metabolite inhibits the reaction [TOP2B protein results in increased hydrolysis of Adenosine Triphosphate]

PMID:29272108
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.