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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: As3mt
Name: arsenite methyltransferase
Acc ID: CHEBI:15414
Term: S-adenosyl-L-methionine
Definition: A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine.
Chemical ID: MESH:D012436
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
As3mtaffects bindingISOAS3MT (Homo sapiens)6480464CTDAS3MT protein binds to S-AdenosylmethioninePMID:22955273 PMID:24124590 PMID:25349987
As3mtmultiple interactionsISOAS3MT (Homo sapiens)6480464CTDCysteine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; Glutathione promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; S-Adenosylmethionine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]PMID:22955273 PMID:25349987
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