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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737111
Species: Homo sapiens
RGD Object: Gene
Symbol: EGR1
Name: early growth response 1
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EGR1increases expressionEXP 6480464CTDOxygen deficiency results in increased expression of EGR1 mRNAPMID:17914565 PMID:19502547 PMID:24236059
EGR1increases expressionISOEgr1 (Rattus norvegicus)6480464CTDOxygen deficiency results in increased expression of EGR1 mRNAPMID:12468449
EGR1multiple interactionsISOEgr1 (Mus musculus)6480464CTD[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of EGR1 mRNAPMID:30529165
EGR1multiple interactionsISOEgr1 (Rattus norvegicus)6480464CTD15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of EGR1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Oxygen deficiency results in increased expression of EGR1 mRNA]; Oxygen deficiency results in increased expression of and results in increased activity of EGR1 protein; troglitazone inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of EGR1 protein]; troglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EGR1 mRNA]PMID:12468449
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