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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732177
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcr4
Name: C-X-C motif chemokine receptor 4
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcr4multiple interactionsEXP 6480464CTD[Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCR4 mRNA; [Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCR4 protein; [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of CXCR4 mRNAPMID:18227068 PMID:30529165
Cxcr4increases expressionISOCxcr4 (Rattus norvegicus)6480464CTDOxygen deficiency results in increased expression of CXCR4 mRNA; Oxygen deficiency results in increased expression of CXCR4 proteinPMID:22745725 PMID:26476374
Cxcr4increases expressionISOCXCR4 (Homo sapiens)6480464CTDOxygen deficiency results in increased expression of CXCR4 mRNA; Oxygen deficiency results in increased expression of CXCR4 proteinPMID:17476338 PMID:17517823 PMID:25047463 PMID:26516004
Cxcr4multiple interactionsISOCxcr4 (Rattus norvegicus)6480464CTDQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 mRNA]; Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 protein]PMID:26476374
Cxcr4multiple interactionsISOCXCR4 (Homo sapiens)6480464CTDarsenic trioxide inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 mRNA]; arsenic trioxide inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 protein]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 mRNA]PMID:22745725 PMID:25047463
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