GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Timp1 | multiple interactions | EXP | | 6480464 | CTD | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of TIMP1 mRNA | PMID:30529165 | Timp1 | increases expression | ISO | Timp1 (Rattus norvegicus) | 6480464 | CTD | Oxygen deficiency results in increased expression of TIMP1 mRNA; Oxygen results in increased expression of TIMP1 mRNA | PMID:16980344 PMID:22911455 | Timp1 | multiple interactions | ISO | Timp1 (Rattus norvegicus) | 6480464 | CTD | 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TIMP1 protein]]; [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in increased expression of TIMP1 mRNA; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TIMP1 protein; [Paraquat co-treated with Oxygen] results in increased expression of TIMP1 mRNA; Mifepristone inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TIMP1 protein]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TIMP1 protein] | PMID:12882763 PMID:27274199 PMID:30229846 PMID:33729688 | |
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