GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | KDR | increases expression | EXP | | 6480464 | CTD | Oxygen deficiency results in increased expression of KDR protein | PMID:31953908 | KDR | increases phosphorylation | EXP | | 6480464 | CTD | Oxygen deficiency results in increased phosphorylation of KDR protein | PMID:8537383 | KDR | multiple interactions | EXP | | 6480464 | CTD | [Apigenin co-treated with Oxygen deficiency] affects the phosphorylation of KDR protein; HIF1A protein affects the reaction [Oxygen deficiency results in increased expression of KDR protein]; KDR protein affects the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; SENP1 protein affects the reaction [Oxygen deficiency results in increased expression of KDR protein] | PMID:23144690 PMID:31953908 PMID:35513012 | KDR | decreases expression | ISO | Kdr (Mus musculus) | 6480464 | CTD | Oxygen results in decreased expression of KDR mRNA; Oxygen results in decreased expression of KDR protein | PMID:22363622 PMID:26272953 | KDR | increases expression | ISO | Kdr (Rattus norvegicus) | 6480464 | CTD | Oxygen deficiency results in increased expression of KDR protein | PMID:34541741 | KDR | multiple interactions | ISO | Kdr (Mus musculus) | 6480464 | CTD | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of KDR mRNA; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of KDR protein; Omeprazole promotes the reaction [Oxygen results in decreased expression of KDR protein] | PMID:19228841 PMID:26272953 PMID:30529165 | | ||||||||||||||||||||||
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