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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68595
Species: Mus musculus
RGD Object: Gene
Symbol: Epas1
Name: endothelial PAS domain protein 1
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Epas1increases expressionEXP 6480464CTDOxygen deficiency results in increased expression of EPAS1 proteinPMID:24503013 PMID:26723917
Epas1multiple interactionsEXP 6480464CTDOxygen deficiency affects the localization of and results in increased activity of EPAS1 proteinPMID:20880076
Epas1affects localizationISOEPAS1 (Homo sapiens)6480464CTDOxygen deficiency affects the localization of EPAS1 proteinPMID:24755467
Epas1affects response to substanceISOEpas1 (Rattus norvegicus)6480464CTDEPAS1 protein affects the susceptibility to Oxygen deficiencyPMID:12679337
Epas1increases expressionISOEpas1 (Rattus norvegicus)6480464CTDOxygen deficiency results in increased expression of EPAS1 proteinPMID:18353899 PMID:23545307
Epas1increases expressionISOEPAS1 (Homo sapiens)6480464CTDOxygen deficiency results in increased expression of EPAS1 mRNA; Oxygen deficiency results in increased expression of EPAS1 proteinPMID:20554536 PMID:20862257 PMID:21994956 PMID:23406266 PMID:23725749 PMID:24403227 PMID:24503013 PMID:36318118
Epas1multiple interactionsISOEpas1 (Rattus norvegicus)6480464CTD[AQP1 protein results in increased stability of EPAS1 protein] promotes the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; [AQP3 protein results in increased stability of EPAS1 protein] promotes the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; [AQP5 protein results in increased stability of EPAS1 protein] promotes the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; Antimycin A inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen inhibits the reaction [AQP3 protein results in increased stability of EPAS1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen inhibits the reaction [AQP5 protein results in increased stability of EPAS1 protein]]; COX10 protein affects the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; EPAS1 mutant form inhibits the reaction [Oxygen deficiency results in increased expression of NTRK2 mRNA]; EPAS1 protein affects the reaction [Oxygen deficiency results in increased expression of CACNA1H mRNA]; myxothiazol inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; Oxygen inhibits the reaction [AQP3 protein results in increased stability of EPAS1 protein]; Oxygen inhibits the reaction [AQP5 protein results in increased stability of EPAS1 protein]; Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; Sodium Cyanide inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; UQCRFS1 protein affects the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]PMID:12679337 PMID:18353899 PMID:23545307 PMID:26095976
Epas1multiple interactionsISOEPAS1 (Homo sapiens)6480464CTD1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; [HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [Oxygen deficiency results in decreased expression of USP28 protein]; [HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [Oxygen deficiency results in increased degradation of MYC protein]; [Oxygen deficiency co-treated with molibresib] results in increased expression of EPAS1 mRNA; [Oxygen deficiency results in increased expression of EPAS1 protein] promotes the reaction [EPAS1 protein binds to USF2 protein]; Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; cobaltiprotoporphyrin inhibits the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]]; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; Cycloheximide inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; EPAS1 affects the reaction [Oxygen deficiency results in increased expression of MYC protein]; EPAS1 gene mutant form inhibits the reaction [Oxygen deficiency results in decreased expression of CPT1A mRNA]; EPAS1 gene mutant form inhibits the reaction [Oxygen deficiency results in decreased expression of FASN mRNA]; EPAS1 gene mutant form inhibits the reaction [Oxygen deficiency results in decreased expression of PPARGC1A protein]; EPAS1 gene mutant form inhibits the reaction [Oxygen deficiency results in decreased expression of SCD mRNA]; EPAS1 gene mutant form inhibits the reaction [Oxygen deficiency results in decreased expression of SREBF1 protein]; EPAS1 mutant form inhibits the reaction [Oxygen deficiency results in increased expression of NEK8 protein]; EPAS1 protein affects the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; EPAS1 protein affects the reaction [Oxygen deficiency results in increased expression of SOD2 mRNA]; Glutathione inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; HMOX1 mutant form inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]]]; IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; Niclosamide inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]; Oxygen deficiency results in increased expression of and affects the localization of EPAS1 proteinPMID:20046830 PMID:20554536 PMID:21994956 PMID:23406266 PMID:23958427 PMID:24236059 PMID:24403227 PMID:24503013 PMID:25451921 PMID:27292261 PMID:36318118
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