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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621445
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Klf4
Name: KLF transcription factor 4
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Klf4decreases expressionEXP 6480464CTDOxygen deficiency results in decreased expression of KLF4 mRNA; Oxygen deficiency results in decreased expression of KLF4 proteinPMID:28478070
Klf4multiple interactionsEXP 6480464CTDepigallocatechin gallate inhibits the reaction [Oxygen deficiency results in decreased expression of KLF4 mRNA]; epigallocatechin gallate inhibits the reaction [Oxygen deficiency results in decreased expression of KLF4 protein]; KLF4 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 mRNA]]; KLF4 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 protein]]PMID:28478070
Klf4decreases expressionISOKLF4 (Homo sapiens)6480464CTDOxygen deficiency results in decreased expression of KLF4 mRNAPMID:34998824
Klf4increases expressionISOKLF4 (Homo sapiens)6480464CTDOxygen deficiency results in increased expression of KLF4 mRNA; Oxygen results in increased expression of KLF4 mRNAPMID:17175027 PMID:27103661
Klf4multiple interactionsISOKLF4 (Homo sapiens)6480464CTDOxygen affects the reaction [AHR protein results in increased expression of KLF4 mRNA]PMID:27103661
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