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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a2
Name: collagen type I alpha 2 chain
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7309846480464CTDOxygen results in increased expression of COL1A2 mRNA

PMID:21439370, PMID:23517783
increases expressionISORGD:7309856480464CTDOxygen deficiency results in increased expression of COL1A2 mRNA, Oxygen results in increased expression of COL1A2 mRNA

PMID:21439370, PMID:24205000
multiple interactionsISORGD:7309846480464CTDCytochalasin D inhibits the reaction [Oxygen results in increased expression of COL1A2 mRNA], exoenzyme C3, Clostridium botulinum inhibits the reaction [Oxygen results in increased expression of COL1A2 mRNA], Oxygen deficiency promotes the reaction [darinaparsin results in increased expression of COL1A2 mRNA], RHOA protein affects the reaction [Oxygen results in increased expression of COL1A2 mRNA], Y 27632 inhibits the reaction [Oxygen results in increased expression of COL1A2 mRNA]

PMID:21439370, PMID:22535156, PMID:23517783
multiple interactionsISORGD:7309856480464CTDY 27632 inhibits the reaction [Oxygen results in increased expression of COL1A2 mRNA]

PMID:21439370
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.